Because of the problems that arising from the use of conventional agricultural systems, demanding of organic farming has increased. To study the effects of organic and biological fertilizers on yield, yield components and essential oil of cumin herb, an experiment arranged based on randomized complete block design with three replications in Zabol University at 2013-2014. The experimental treatments included 1-Pseudomonas bacteria (Pseudomonas putida) 2-Azotobacter bacteria (Azotobacter chroococcum) 3-compost 4-vermicompost 5-combination of Pseudomonas and Azotobacter 6-Pseudomonas and compost mix 7- combination of Pseudomonas and vermicompost 8-combination of Azotobacter and compost 9-combination of Azotobacter and vermicompost 10-combination of compost and vermicompost 11-control (no fertilizer treatments) respectively. The results showed that plant height, number of umbels per plant and number of seeds per umbel was increased significantly under organic and biological fertilizers application. The combined application of compost and vermicompost increased 21.9, 27.59 percent seed yield, biological yield compared to the control, respectively. Using of organic and biological fertilizers decreased oil percentage of essential oil so that the non-application of fertilizer (control) showed the highest percentage of oil. 1000-grain weight and harvest index were not affected by the use of organic and biologic fertilizers so, regarding to the results of this study combined nutrition of biological and organic fertilizers, especially combined use of compost and vermicompost to increase performance and maintain long-term production without pollution is better in similar circumstances.