This experiment was conducted to evaluate the effects of Fe and Zn foliar spraying on yield, yield components and essential oil quality of cumin under drought condition based on split plot arrangement in randomized complete block design with three replications at Zabol University Research Farm in 2012. Drought stress as a main factor included three irrigation intervals of 5, 10 and 15 days and micro-nutrients spraying as a sub factor included 4 levels of non-spraying (control), Fe spraying, Zn spraying and their combination. The results indicated that increasing drought stress reduced plant height, number of umbels per plant, 1000 seed weight, seed and biological yield. The effects of micro-nutrients spraying on plant height, number of umbels per plant, number of seeds per umbels, seed and biological yield, harvest index and essential oil yield and percentage was significant and the greatest seed yield (833.8 kg/ha) was obtained at plant sprayed with Zn. Interaction of micro-nutrients spraying and drought stress was significant on number of seeds per umbels, 1000 seed weight and biological yield and the greatest biological yield was obtained at 5 days irrigation intervals and Zn spraying.